Trial? Trial?

Na het vorige bezoek heb ik me verdiept in de trial voor het nieuwe medicijn waar ik mogelijk aan mee kan gaan doen. Gelukkig is alles openbaar en op internet te vinden. Ook de inclusie en exclusie criteria die zijn bepaald door de farmaceut die het medicijn op de markt wil brengen. Daarin las ik dat er wereldwijd voor deze trial maar 270 patiënten worden gezocht. Dat is wel heel erg weinig, en op mijn aandringen hebben we de intake-afspraak vervroegd.
Ben gewoon bang dat ik straks door de screening heen ben gekomen en dat men zegt “sorry, maar u bent nummer 271”.
Vandaag de intake gehad. Goede voorlichting en alle (inmiddels bij mij bekende criteria) worden doorgenomen. Zo moet het Hb onder de 6.2 zijn (was nu 5.7), de milt moet groot zijn en minimaal 5 cm onder de ribbenboog uit steken (voldoet), minimaal nog 6 maanden te leven hebben (gelukkig wel), en er moeten een aantal “secundaire” verschijnselen zijn zoals zware vermoeidheid, afvallen, verminderde eetlust en nog een aantal (heb ik ook).
Volgens de hematoloog voldoe ik zo op het eerste gezicht aan alle criteria die door de farmaceut gesteld zijn en we kunnen verder. Ter plekke onderteken ik een verklaring dat ik mee wil werken aan de trial en de bijbehorende onderzoeken. Een uitgebreid schema maakt onderdeel uit van de documentatie. De eerste vier weken na goedkeuring door de farmaceut iedere week een bezoek aan het ziekenhuis. Totaal in 36 weken 4 maal een MRI, 14 maal bloedonderzoek, 2 maal beenmergpunctie, 4 maal ECG. Ze houden je wel in de gaten met het testen van nieuwe medicijnen 😉
Als eerste moeten er nu metingen gedaan worden om definitief goedkeuring te krijgen van de farmaceut dat ik mee mag doen.  De verschillende onderzoeken, waaronder een beenmergbiopt, worden nu ingepland. Het ECG (hartfilmpje) hebben we gelijk al laten maken.

De trial bestaat overigens uit een vergelijkende test. Door loting bepaalt men of je het medicijn mag uitproberen (2 van de 3 patiënten) of dat je in de groep valt die “de beste, beschikbare behandeling” krijgt (1 van de 3 patiënten dus zonder het nieuwe medicijn). Hopen dus dat ik mee mag doen met het nieuwe medicijn.

Ben blij dat er nu iets in gang wordt gezet. Er moet ook iets gebeuren want ik ga wel hard achteruit. Naast mijn vaste ochtendritme waarin ik energie spaar door vrijwel niets anders te doen dan TV kijken en krant lezen, moet ik nu ook aan het einde van de middag rusten om de dag verder door te komen. Vermoeidheid is een van de grootste problemen die ik heb. Hier kampen overigens alle Myelofibrose patiënten mee. De medicijnen zouden hierbij verbetering moeten geven. Laten we het hopen!

Bij deze controle is het Hb (energie) weer gezakt van 6.1 naar 5.7, maar zijn de plaatjes iets gestegen naar 98. De witte (weerstand) doen het nog steeds goed 7.3.

Binnenkort het vervolg van alle onderzoeken die nodig zijn om te bepalen of ik mee mag doen met de trial.

Toevallig precies nu een leuk boek aan het lezen. John Grisham “Claim”. Gaat over mega claims die advocaten bij farmaceuten neerleggen (uiteraard in Amerika) voor het op de markt brengen van medicijnen die niet deugen……

332 gedachten over “Trial? Trial?

  1. Não sou como tu João!Eu sou de Aveiro, não sou de Lisboa nem do PogmO.orrulho-te de ter estado em duas finais recentes e ter ganho uma!

  2. KJ już po spadkach EBC skupuje obligi zatem sztuczna hossa ale hossa zatem warto kupować. Szczególnie nasze akcje bo są mocno niedowartościowane. Mamy przed sobą 4 lata stałych wzrostów jak mi podpowiadają moje obliczenia. Do 2016 będziemy rosnąć i rosnąć z małymi korektami.

  3. As with any designer. You love to try something new. otherwise it will get boring. I remember doing a valentine table setting event. Instead of the usual color of pink and red. I went with a beige napkin with brown ribbon on a black charger. I ‘ll be happy to share photo if requested.

  4. July 16, 2011 How often we ask “How are you?” when we really don’t care, and don’t want to know. .I have found that rather than have the answer all the time, the challenge is to really listen. Really care. And ask if there is a way for me to help. And mean it.Absolutely love the answer. We do look for the resurrection!! Praise Him!Thanks Glen,Craig

  5. Genial!@Sascha Danke!@Ralf Ebenfalls danke. Ich denke, gäbe es nicht so viele Browser hätten wir möglicherweise weniger zu tun, aber die Webwelt wäre um einiges langweiliger. Es ist doch ganz gut so wie es ist, würde ich sagen.

  6. Hi there! I could have sworn I’ve visited this blog before but after browsing through many of the articles I realized it’s new to me. Nonetheless, I’m certainly delighted I found it and I’ll be book-marking it and checking back often!

  7. 06/05/2011 – 12:29pmLas acusaciones al Barça de doping vinieron despues de una serie de reportajes en Marca acerca del dopaje. ¿Empezaremos a ver ahora este tema de la compra de partidos?Ahí lo dejo.

  8. Kita tidak terkejut jika pasukan pembelaan akan sekali lagi mencari helah/diarah untuk menangguhkan perbicaraan. Namun agak pelik apabila seorang yang mengaku terhormat, warak dan bersih tampak begitu takut untuk menghadapi perbicaraan, sama takutnya untuk memberikan sampel untuk tujuan dna.

  9. Snoopy Dance | “The Embassy of the United States in Cairo condemns the continuing efforts by misguided individuals to hurt the religious feelings of Muslims – as we condemn efforts to offend believers of all religions,”“Condemn…efforts” ≠ “apology for 1st Amendment”…except in that parallel universe conservatives inhabit.And “Cairo Embassy” ≠ “Obama”. You get more and more obtuse with every trope you repeat. Where do I get the RNC Dictionary with all the new definitions of common words and concepts?But it’s your lie…tell it any way you like.

  10. jeanne,you are amazing.this piece was devastatingly beautiful… your perspective on death and dying, on life and living (because, as you so expertly show, they are irrevocably connected) is rare and amazingly soul-affirming. sharon gathered herself a menagerie of kindred spirits throughout her life, and her story (which is your story, which is their story, too, of course) is just…. unforgettable.thank you.so so much.for sharing sharon, for sharing your self.<3

  11. Light relief and enjoyable after the monthly Saga puzzle.The two 15 letter answers (top and bottom) were initially found, giving a good starting point for remainder of the grid.Favourite clue probably 26 across.

  12. Eikö elukoista ole ikiajat käytetty kaikki irtoava hyödyksi? Miksi se nyt on yhtäkkiä paha asia jos makkaraan laitetaan kaikki syötäväksikelpaava? Jos näin ei olisi niin hipit olisivat itkemässä kun yhyyyy, Putesta ja Mansikista menee niin paljon hukkaan.

  13. I live in Ireland and I buy all my natural products from iherb.com at great prices.For my skin I mixed and melted together: shea butter,cocoa butter with jojoba oil and coconut oil and I got a great moisturiser for face,body and hair.check the prices at iherb.com and if you’ll order, use cod KEB068 for 5 $ off on your first purchase.I got my package in just two days.really happy with everything I bought.just give it a try

  14. – once the threat ceases to be a threat, the justification for lethal force ceases as well. Tam has actually had to draw her sidearm in her own defense before. If I had a choice, I'd rather have someone with her demonstrated self-discipline and her understanding of the use of lethal force in a Castle Doctrine state over someone with a cavalier "NOW can I shoot?" attitude in my platoon.gvi

  15. 20 augusti alltså, jag som nästan attackerade brevbäraren idag men sen surmulet fick gå in igen utan ikeakatalog. Jag får vänta lite till. Det är okej, jag har tydligen fått dille på att måla om lite här hemma, dörrkarmar och så.Kram

  16. This makes me so happy! I love that they wanted to BE SEEN for her birthday. So awesome!And to Ari… I'm not even close to my 60s, but your blog is really inspiring for a younger person to wear awesome outfits at any age. People who see my collection of brightly coloured tights and shoes, and often comment, "Oh, I can't wear bright colours," and I ask, "WHY NOT?" And then I direct them to your blog. 🙂

  17. Lieber das Buch, da steckt meistens deutlich mehr an Informationen drin. Photoshop habe ich seit Ewigkeiten nicht mehr upgedatet, da ich lieber auf dem iPad und ausser Haus zeichne 😉 Jetzt mit Adobe Touch und insbesondere Adobe Ideas komme ich aber wieder auf den Geschmack.

  18. I have both a personal profile and a business page. Many of my business acquaintances send friend requests to my personal page. How can I redirect them to my page and/or is there a way to accept their friend request but then filter them so they don’t get all my personal stuff?

  19. In general, pizza ovens are gas or electric styles or wood models. Coal even been used as a heat source. Wood fired oven pizza is excellent, some, but delicious pizzas can be prepared almost any style pizza oven. Try this incredible new discovery: Cone Pizza!

  20. I saw another execution over the weekend. Similar (or maybe the same?) group of guys stuck in a tent in the Antarctic like Scott. They don’t want to go out until one of the gang reminds the rest it’s his birthday. Again, it’s better than the starlings. But I agree with Anonymous 2:02 – ’Belong’ would be have more impact without the heavy-handed end line.

  21. When we were growing up we would have an easter egg hunt and the eggs had pennies inside of them. Anywhere from 1-3 pennies. The big winner egg was an egg that had a 50 cent piece in it. My brother would always find it.

  22. Simply wish to say your article is as surprising. The clearness in your post is simply nice and i could assume you’re an expert on this subject. Well with your permission allow me to grab your RSS feed to keep up to date with forthcoming post. Thanks a million and please continue the rewarding work.

  23. Phil – please have a read of this article by Joseph Massad and let us know if you still think Obama is a love machine. I’m not convinced.Note the article’s sub-title: Although Palestinian children endure lives of suffering, Obama’s love for their Israeli counterparts knows no limit.

  24. Guy Môquet nous a fait perdre la tête. C’est une victoire posthume et pour cette fois les communistes étaient du côté argentin (qui n’ont plus de junte).La prochaine fois on jouera aux Malouines. A balles réelles ?

  25. Yes – thanks for the advice, dearest Eric, March inches forward, slowly does it… Yesterday was offered some interesting, well-paid work, but won’t see any pay till December (I should live so long..!). Of course, I accepted it – but I’m hanging on in there, am sure there’s more to come – slowly does it, faith and patience.

  26. All the ads for “Country Strong” and it did not even get 1,500 theaters? I have to ask is her song being played on country music stations? Could surprise in midwest/south I guess.I have to agree with Chuck, saving money for Green Hornet, just hoping it can get even average reviews.

  27. Unhas das características dos superfluídos é que poden atravesar obxectos sólidos e superficies non porosas debido á súa gran capacidade de oscilación. Por outra banda, o xeo quente fórmase a partir da rápida cristalización dunha disolución hiper-saturada, que posteriormente se arrefriou, de acetato de sodio e auga quente.

  28. Burma in public in Rangoon, Burma, a city where you can find halal shops everywhere..Now the women's group Akhaya think they may have found a solution. Women blow their flute as soon as they feel the harassment. This will alarm the other bus passengers who can come to the women's rescue.Norwegian Church Aid helps out with the flute project.Something to think about also for Europe?

  29. John Mansfield–because none of the adults’names were ever turned over to police. THAT would have been the appropriate child-protective course of action, not writing their names in a file and telling them, essentially, to move along. Professionals who work with children (doctors, teachers, etc) are MANDATED REPORTERS: we MUST inform the police if we have reason to suspect child abuse. It is unlawful for us not to. Yes, it turns up a number of false positives. But it is a safer alternative to just hoping it doesn’t happen again.

  30. May 14th, 2008 at 10:13 am# 80 You may be right that the numbers cannot be dismissed out of hand. Nevertheless, I remain wary, given the pressure on developers to discount and move units, homeowners pushed into short sales, etc. I guess I am back to the position taken by Reagan some years ago: Доверяй, но проверяй (doveryai, no proveryai). It will be interesting to see some granular analysis of the data.Правильной дорогой идете, Товарищ!!!

  31. C’est bon j’ai enfin vu le pilot de ces 3 nouvelles séries, et je pense que la seule que je vais continuer va être Arrow, le premier épisode est convaincant avec quelque petite faiblesse, reprendre le chateau des Luthor de Smallvlle était un peu gros mais bon ils ont apparemment changé l’intérieur. Concernant Beauty and the Beast, pilot très moyen même si j’ai toujours aimé Kristin Kreuk sa sera sans moi et Emily Owen M.D était effectivement du sous Grey’s Anatomy

  32. Mình vừa check lại link thấy ổn mà cậu, nếu ý cậu nói link từ tập 7 đến tập 12 thì không phải bị die đâu, là do bị chặn thôi. Cậu nên vào link folder, save file về acc riêng của cậu thì mới download được >v<

  33. Sinusta “AI” on ok jos Raamattua erehtymättömänä pitävä kasvatustieteen (jota kaikki opet joutuu opettelemaan yliopistoissa) proffa haistattaa luonnonhistoriaa koskevalle luonnontieteelle pitkät (koska ristiriidassa Raamatun sanan kanssa) ja toivoo (Raamatullisen) luomisopin saavan jalansijarakoa kouluissa tiedetunneilla vähän kuin keskiajalla.. ??”Perimmäinen tarkoitus” on luettavissa myös kaikista muista TP:n sanomisista Kalevassa, uskonsaittien haastatteluissa ym.Ei pelkän kirjan varassa tarvi.. tyhymä sinisilimä oot jos niin meet maailman läpi.Skepsis ei oo sinisilimä niinku sä.

  34. intriguing adventure Looking fo relationship advice for women r some sort of adventurous female to nd adult theatre together with. Im safe discease % free professional and sincere. Maybe you really are curious a serious relationship nd wish to see what the nation’s about. Im the guy! interracial married swinger , zip 40864, 29809 black women in Van Horn

  35. First time reader,found you through the new Bourque site, BC Newswatch. I need your address to send you a bill since I have spent the last two hours reading through your work instead of doing mine. Fantastic – compelling and in some cases top notch investigative work that should be page 1 section 1. Glad to have made the aquaintence, nice to have another west coast place to stop. I’m on the Hill, and this is a view I haven’t seen before. Cheers!

  36. He’s completely beat to shit; the team doesn’t want him there anymore; his coach is on the doorstep of unemployment; and the owner is bleeding money…..He might as well jump ship now…it would only be more humiliating the longer he goes.At best they get 5 maybe 6 wins….What’s the point.Plus, he needs to get prepared for this messy divorce that’s coming.

  37. Noen ganger er turer bra, andre ganger ikke, jeg er litt opp og ned der…..f eks var det i gÃ¥r veldig behagelig Ã¥ kjøre rundt pÃ¥ viddene i en løypemaskin, istedenfor Ã¥ ta skiene fatt……masse fin natur, men godt og varmt……Synes du var lur som sendte mann og barn ut, sÃ¥ du selv kunne nyte livet til det du selv ville.Ha en god søndag.

  38. . Your favorite justification appeared to be onthe internet the simplest thing to be aware of. I say to you, I definitely get annoyed while people thinkabout worries that they just do not know about.You managed to hit the nail upon the top as well as defined out the whole thing without having side-effects ,people could take a signal. Will probably be back to get more.Thanks

  39. Your new blog post pertaining to Cool Free Stuff – Free Cookbook Download! Easy Sweets! indeed gave me food for thought. I don’t frequently comment on blog sites nonetheless figured I should inform you that I concur totally with the majority of of your strategies.Not sure that I agree with every position you try to make though – Hang Blodgett

  40. After examine a couple of of the blog posts in your web site now, and I truly like your way of blogging. I bookmarked it to my bookmark web site listing and might be checking back soon. Pls check out my web page as well and let me know what you think.

  41. Yeah! Rock n’ Roll! Another great workout and a great series of videos! And you’ve definitely put on some size! You seem to have lots of energy Kev. Love the words of wisdom.Just awesome. What more can I say. I’m off to do legs in a few hours. Hardly ever been so excited about going to the gym.Now get some rest and grow!!

  42. Just to be clear, The Stephen above is not me, Stephen B., me being the person active in the blog discussion over the past few weeks.Not that I agree or disagree with anything in particular above.

  43. It’s not as if the Tales series hasn’t had magical swords as characters before – it was a major part of Tales of Destiy after all. The sacrificial girl is an unfortunate recurring toxic trope in JRPGs (and elsewhere) however so it’s good to point it out. It sounds like Collette is heading down the same path as Aeris from FF7, Mina from Breath of Fire 2, Lucia from Lunar: Eternal Blue and numerous others.

  44. I don't know … my kids swim on a club swim team. It is very much an individual sport with the team/friends aspect. Girl child is taking up junior roller derby too. It is a team sport and a little quirky and lots of fun.

  45. Les médecins sont en pointe sur ce sujet même si, vous l’avez compris, l’ensemble de la communauté scientifique se sent concernée. Les médecins sont en pointe car beaucoup d’entre eux ressentent qu’ils ont le devoir de protéger la société contre le charlatanisme. C’est bien le cas quand des peurs sont agitées à partir d’études non concluantes ou lorsque des associations recrutent des militants sur les basses d’allégations de santé mensongères.

  46. Pingback: Google
  47. Pingback: best lubricant gel
  48. Pingback: plug toy
  49. Pingback: best blindfold
  50. Pingback: impresoras
  51. Pingback: sex feather duster
  52. Pingback: 50+ singles
  53. Pingback: 925 silver jewelry
  54. Pingback: todomazda
  55. Pingback: pracovni plosiny
  56. Pingback: autoplosiny
  57. Pingback: Cummins ism
  58. Pingback: lovedoll
  59. Pingback: morkie dog
  60. Pingback: anal plug
  61. Pingback: PARTY DJ
  62. Pingback: apps for windows 8
  63. Pingback: dental x-ray
  64. Pingback: 스포츠닥터스
  65. Pingback: buy kona coffee
  66. Pingback: pure kona coffee
  67. Pingback: Rabbit Toy
  68. Pingback: Checked rug
  69. Pingback: sex toys
  70. Pingback: ashlynn brooke
  71. Pingback: pc games download
  72. Pingback: free tech forum
  73. Pingback: CISO Terbaik
  74. Pingback: beagle dog
  75. Pingback: robots systems off
  76. Pingback: chug
  77. Pingback: pdr training
  78. Pingback: the rabbit sex toy
  79. Pingback: sex toy
  80. Pingback: Class 6
  81. Pingback: malayalam movies
  82. Pingback: PHP Muisc CMS
  83. Pingback: 24/7 service
  84. Pingback: Hallelujah
  85. “Great Blogpost! Hello there! Do you use Twitter? I’d like to follow you if that would be ok. I’m definitely enjoying_ your blog and look forward to new posts.”

  86. Pingback: smell proof bags
  87. Pingback: couples
  88. Pingback: SAI
  89. Pingback: app for pc
  90. Pingback: sexshop curitiba
  91. Pingback: best of 100% kona
  92. Pingback: kona coffee beans
  93. Pingback: strap on
  94. Pingback: clit vibrator
  95. Pingback: dick extension
  96. Pingback: Best Anal Plugs
  97. Pingback: air conditioner
  98. Pingback: nike air jordan
  99. Pingback: mulvadi 100% kona
  100. Pingback: spinning vibrators
  101. Pingback: work at home 2017
  102. Pingback: anal plug
  103. Pingback: peru travel
  104. Pingback: couples
  105. Pingback: clit
  106. Pingback: best anal sex toys
  107. Pingback: Stroker Kit
  108. Pingback: masturbation
  109. Pingback: sex comedy
  110. Pingback: male vacuum pump
  111. Pingback: Vibrating Sex Toy
  112. Pingback: women climax
  113. Pingback: szybka chwilowka
  114. Pingback: sex comedy
  115. Pingback: eshop cy
  116. Pingback: designer
  117. Pingback: forex signal
  118. Pingback: Advertise Online
  119. Pingback: amazon wish list
  120. Pingback: gaming laptops
  121. Pingback: microfoane spion
  122. Pingback: backgammon game
  123. Pingback: best smm panel
  124. Pingback: clit
  125. Pingback: Cheryl Barnes
  126. Pingback: sex blindfold
  127. Pingback: bunny sex toy
  128. Pingback: Best Anal Beads
  129. Pingback: dildos
  130. Pingback: sex confession
  131. Pingback: bedroom fengshui
  132. Pingback: Best pizza
  133. Pingback: apps for pc
  134. Pingback: 福井脱毛
  135. Pingback: 福井脱毛
  136. Pingback: 福井脱毛
  137. Pingback: 福井脱毛
  138. Pingback: China Import Agent
  139. Pingback: 福井脱毛
  140. Pingback: work at home 2017
  141. Pingback: Buy rap beats
  142. Pingback: 100% kona
  143. Pingback: buyers
  144. Pingback: glendale
  145. Pingback: buy kona
  146. Pingback: sex talk
  147. Pingback: Android repair
  148. Pingback: Sprinklers
  149. Have you ever considered writing ann ebook or guest authoring on other websites?
    I have a blogg based on the same ideas you discuss and would rsally like
    to have you share some stories/information.Iknow my viewers would enjoy your work.
    If you are even remotely interested, feel free to send me
    an e-mail.

  150. Pingback: Cams

Reacties zijn gesloten.